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10.1039/c9nr00004fSCI21-FebArnbjerg J, 2006, J PHYS CHEM A, V110, P7375, DOI 10.1021/jp0609986; Aslan K, 2007, J AM CHEM SOC, V129, P1524, DOI 10.1021/ja0680820; Aslan K, 2009, CHEM SOC REV, V38, P2556, DOI 10.1039/b807498b; Bauch M, 2014, PLASMONICS, V9, P781, DOI 10.1007/s11468-013-9660-5; Chen HJ, 2013, CHEM SOC REV, V42, P2679, DOI 10.1039/c2cs35367a; Collins HA, 2008, NAT PHOTONICS, V2, P420, DOI 10.1038/nphoton.2008.100; Deng W, 2013, PHYS CHEM CHEM PHYS, V15, P15695, DOI 10.1039/c3cp50206f; FISCHER A, 1995, APPL OPTICS, V34, P1989, DOI 10.1364/AO.34.001989; Gao D, 2006, NANO LETT, V6, P2383, DOI 10.1021/nl0617179; Garcia-Parajo MF, 2008, NAT PHOTONICS, V2, P201, DOI 10.1038/nphoton.2008.37; Gu B, 2017, ADV MATER, V29, DOI 10.1002/adma.201701076; Gu BB, 2016, ADV OPT PHOTONICS, V8, P328, DOI 10.1364/AOP.8.000328; Jung BK, 2016, ACS NANO, V10, P10533, DOI 10.1021/acsnano.6b06530; Li Q, 2015, ADV OPT MATER, V3, P801, DOI 10.1002/adom.201400505; Lombardi A, 2012, LANGMUIR, V28, P9027, DOI 10.1021/la300210h; Mishra H, 2013, PHYS CHEM CHEM PHYS, V15, P19538, DOI 10.1039/c3cp50633a; Qin J., 2017, NANOSCALE, V65, P13991; Siddiquee AM, 2015, J PHYS CHEM C, V119, P28536, DOI 10.1021/acs.jpcc.5b08214; Wu KCW, 2014, CHEM COMMUN, V50, P4148, DOI 10.1039/c4cc00005f; Xu C, 1996, J OPT SOC AM B, V13, P481, DOI 10.1364/JOSAB.13.000481; Xu YK, 2014, ACS APPL MATER INTER, V6, P5619, DOI 10.1021/am500106c; Yu H., 2016, ACS NANO, V10, P10489; Zhao TT, 2014, ACS APPL MATER INTER, V6, P2700, DOI 10.1021/am405214w; Zhou GJ, 2013, ACS APPL MATER INTER, V5, P13340, DOI 10.1021/am404282j2470874731173395Nanoscale33862019METAL-ENHANCED FLUORESCENCE; CROSS-SECTIONS; PHOTOSENSITIZERS; ABSORPTIONREORTSOM219122Recent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (TP-PDT). However, traditional photosensitizer (PS)-based TP-PDT remains a critical challenge in clinics due to its low two-photon absorption cross sections. Here, we propose that the therapeutic activity of the current photosensitizer, sulfonated Al-phthalocyanine (AlPcS), can be efficiently excited via plasmonic-resonance energy transfer from the two-photon excited gold nanobipyramids (GBPs) and further generates cytotoxic singlet oxygen for cancer eradication. GBPs possess large two-photon absorption cross sections, excellent photostability, and biocompatibility, which can be used for a high two-photon light-harvesting material in biomedical applications. We compared the in vitro and in vivo capabilities of AlPcS-loaded GBPs as a TP-PDT agent for theranostic applications by benchmarking them against those of the extensively studied gold nanospheres (GNS) and nanorods (GNR). Although all these Au nanostructures could cause enhanced PS two-photon excitation fluorescence and improved singlet oxygen generation capability via the plasmonic resonance-energy transfer process, GBP-AlPcS exhibited the highest two-photon efficiency for photodynamic therapy. Remarkably, in vivo experiment results clearly indicated that the GBP-AlPcS caused efficient suppression of tumor growth and minimal adverse effects on orthotopic A549 human lung tumor xenografts. The system presents great efficiency in improving the treatment depth and precision of traditional photodynamic therapy.AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo期刊论文EnglishWang, Jing; Zhuo, Xiaolu; Xiao, Xiao; Mao, Rihua; Wang, Yong; Wang, Jianfang; Liu, Jun WOS:000459580000031
外文题目: AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo
作者: Wang, Jing; Zhuo, Xiaolu; Xiao, Xiao; Mao, Rihua; Wang, Yong; Wang, Jianfang; Liu, Jun
刊名: Nanoscale
年: 2019 卷: 11 期: 7 页: 3386--3395
英文关键词:

METAL-ENHANCED FLUORESCENCE; CROSS-SECTIONS; PHOTOSENSITIZERS; ABSORPTION
英文摘要:
文献类型: 期刊论文
正文语种: English
收录类别: SCI  21-Feb
DOI: 10.1039/c9nr00004f
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